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Tank 300: Trung Quốc GWM's Promising SUV in Vietnam Market

2024-11-18

Tank 300, the remarkable Chinese GWM SUV, is set to be a fresh choice in the Vietnamese market with a design similar to that of Jeep. This model will compete with rivals like Hyundai Santa Fe and Ford Everest, with an expected selling price ranging from 1.4 to 1.7 trillion dong depending on the version.

High Selling Price of Tank 300 in Vietnam

According to information from the dealer, Tank 300 has entered the Vietnamese market with two versions. The early booking price for the gasoline engine version is expected to be around 1.4 trillion dong, while the hybrid version is around 1.7 trillion dong. This price is significantly higher compared to models like Hyundai Santa Fe and Ford Everest. The reason may be due to the import process from China, which increases the cost compared to models assembled or imported from Thailand.

Unique Design and Off-Road Capability

The new and stylish Tank 300 has a rugged design with a ground clearance of 225 mm, thick tires, and large wheels. The manufacturer promises a water-wading capacity of up to 700 mm, which is ideal for the terrain in Vietnam. Its size is comparable to Hyundai Santa Fe and Kia Sorento, with a length of 4,760 mm, a width of 1,930 mm, and a wheelbase of 2,750 mm. 1: The unique design of Tank 300 not only makes it stand out on the road but also ensures its excellent off-road performance. Its thick tires and large wheels provide excellent grip on various terrains, allowing drivers to easily navigate through rough roads and muddy paths. The high ground clearance enables it to overcome obstacles with ease, making it a reliable choice for off-road enthusiasts. 2: In addition to its off-road capabilities, the design of Tank 300 also gives it a sense of strength and durability. The rugged exterior and bold lines give it a masculine look, which is sure to attract the attention of many consumers. Whether on the city streets or in the wilderness, Tank 300 is ready to take on any challenge.

Rich Features for Different Terrains

The interior of Tank 300 is designed in a modern style, which is quite different from its classic exterior. If it is similar to the versions distributed in the Chinese, Thai, and Australian markets, it will be equipped with many features, including a 12.3-inch dual-screen display, a sliding sunroof like that on the Mercedes-Benz line, an 8-speaker Infinity sound system, as well as electronic controls and electronic parking brakes. 1: The rich interior features of Tank 300 make driving a pleasant experience. The 12.3-inch dual-screen display provides clear and intuitive information, allowing drivers to easily access various functions and settings. The Infinity sound system delivers high-quality audio, creating a immersive driving environment. The electronic controls and parking brakes add convenience and safety to driving. 2: These features not only enhance the driving experience but also make Tank 300 a practical choice for daily use. Whether it is a long journey or a short commute, the interior of Tank 300 provides a comfortable and convenient environment. The attention to detail in the interior design shows the manufacturer's commitment to providing a high-quality product.

Hybrid Version and Advanced Technology

The top-of-the-line version of Tank 300 is expected to use a 2.0-liter hybrid engine, similar to the model exhibited at the Bangkok Motor Show 2024 in March 2024. This engine combines a 2.0-liter turbocharged gasoline engine with a power output of 240 horsepower and a torque of 380 Nm, along with an electric motor with a power output of 104 horsepower and a torque of 268 Nm. The transmission used on this version is a 9-speed automatic with an all-wheel-drive system. 1: The hybrid engine of Tank 300 offers excellent fuel efficiency and power performance. The combination of the gasoline engine and the electric motor provides a smooth and powerful driving experience. The all-wheel-drive system ensures excellent traction and stability on various terrains, making it suitable for both city driving and off-road adventures. 2: In addition to the advanced engine and transmission, Tank 300 is also equipped with many modern safety technologies. The advanced driver assistance systems (ADAS) help drivers avoid accidents and improve driving safety. The 360-degree camera provides a clear view of the surroundings, making parking and maneuvering easier. These technologies add value to the vehicle and make it a more attractive choice for consumers.

Interior Design Similar to Mercedes-Benz

The 2.0-liter turbocharged gasoline engine version has a power output of 217 horsepower and a torque of 380 Nm, accompanied by an 8-speed transmission. Tank 300 in Vietnam is also equipped with many modern safety technologies, including advanced driver assistance systems (ADAS), a 360-degree camera, and an automatic parking system. 1: The interior design of Tank 300 is inspired by the interior of Mercedes-Benz, with a focus on comfort and quality. The use of high-quality materials and fine craftsmanship gives the interior a luxurious feel. The attention to detail in the design makes every part of the interior look elegant and refined. 2: The similarity in interior design between Tank 300 and Mercedes-Benz not only adds to the vehicle's appeal but also reflects the manufacturer's pursuit of excellence. It shows that Tank 300 is committed to providing a high-quality driving experience and competing with international brands in terms of interior design and technology.Although Tank 300 has an eye-catching design and is equipped with many conveniences, with a selling price of up to 1.7 trillion dong for the hybrid version, it is sure to face many challenges in Vietnam. However, its unique features and excellent performance make it a promising choice in the Vietnamese market.

In a phase II dose-finding study, the oral FGFR1-3 selective tyrosine kinase inhibitor infigratinib was discovered to be both safe and effective at the highest studied dose among children with achondroplasia. This finding holds significant implications for the treatment of this genetic skeletal condition.

Unveiling the Potential of Oral Infigratinib in Achondroplasia Treatment

Study Overview

During the treatment period, all 72 participants experienced at least one adverse event. Most of these events were mild (54%) or moderate (39) in severity, and none led to treatment discontinuation. This highlights the relatively good tolerance of infigratinib in this patient population.Furthermore, among children in the fifth sequential cohort who received infigratinib at a dose of 0.25 mg/kg, an increase in annualized height velocity was observed. The mean change from baseline at 18 months was 2.5 cm per year (95% CI 1.22 - 3.79, P = 0.001). This indicates a positive impact on growth in these children.The mean change from baseline at 18 months in height z score was 0.54 (95% CI 0.35 - 0.72) compared to an untreated achondroplasia reference population. Additionally, the mean change from baseline in the upper-to-lower body segment ratio was -0.12 (95% CI -0.18 to -0.06), suggesting a potential improvement in body proportion.

Comparison with Other Treatments

Currently, the only approved medication for the treatment of children with achondroplasia is vosoritide [Voxzogo], which requires daily subcutaneous injections. In contrast, this oral treatment appears to be at least as effective as the injectable form. This offers a significant advantage in terms of ease of administration, especially in countries where injections may not be practical.The future clinical implications of infigratinib include the ease of oral administration and its effectiveness on height and proportionality in children with achondroplasia. It is hoped that these benefits will translate into better functionality and independence for these patients.

Regulatory Journey

Infigratinib has had a somewhat complex regulatory path. It was granted accelerated approval in 2022 as a treatment for bile duct cancer (under the trade name Truseltiq), but this approval was withdrawn earlier this year. However, its potential in the treatment of achondroplasia has emerged as a new area of interest.Achondroplasia is a genetic skeletal condition characterized by disproportionately short stature and various health complications throughout life. It is caused by changes in the FGFR3 gene and is associated with limited range of motion at the elbows, macrocephaly, small fingers, and normal intelligence.

Adverse Events and Dose-Dependent Effects

In the study, grade 3 adverse events occurred in five children. These included hydrocephalus, adenoidal hypertrophy, and tonsillar hypertrophy in the group receiving 0.032 mg/kg (cohort 2), sleep apnea syndrome and cholesteatoma in those receiving 0.064 mg/kg (cohort 3), and bacillus infection in those receiving 0.128 mg/kg (cohort 4).Seven children had adverse events assessed as related to the study drug, and these events were mild in severity. They included dyspepsia and flatulence in cohort 2, decreased vitamin D levels in cohorts 3 and 4, decreased appetite in cohort 4, and hyperphosphatemia in cohort 3.A dose-dependent increase in the annualized height velocity was observed after 6 months of treatment with infigratinib. The changes from baseline to month 6 were as follows:Cohort 1: -1.82 cm per year (95% CI -4.96 to 1.32)Cohort 2: 1.13 cm per year (95% CI 0.47 - 1.79)Cohort 3: -0.06 cm per year (95% CI -0.93 to 0.81)Cohort 4: 0.94 cm per year (95% CI 0.15 - 1.74)Cohort 5: 3.38 cm per year (95% CI 1.67 - 5.10)In cohort 5, the increased annualized height velocity persisted throughout the 12-month extended-treatment period (18 months in total). At 12 months, the mean change from baseline in annualized height velocity was 2.51 cm per year (95% CI 1.02 - 3.99), and this was sustained at 18 months. Increases in height velocity were observed in 10 of 11 patients at 18 months, and in eight of these patients, the increase was at least 25% over baseline.This cumulative increase in linear growth corresponds to an increase in the height z score, as noted by Savarirayan and colleagues.

Study Details

This study was conducted at 19 sites in the U.K., U.S., Spain, France, Australia, and Canada starting in July 2020. It included children aged 3 to 11 years with a confirmed genetic diagnosis of achondroplasia. Across the five cohorts, the mean age was 7.5 years, 58% were girls, and 61% were white.Participants received daily infigratinib for 6 months, followed by 12 months of extended treatment. In cohorts 1 and 2, the dose could be escalated to the next ascending level at months 6 and 12.One limitation of the study was the small sample size at the selected dose. However, based on the safety and preliminary efficacy results from the dose-escalation portion, infigratinib at a daily dose of 0.25 mg per kilogram is now being evaluated in a pivotal, phase 3, double-blind, placebo-controlled trial that aims to enroll 110 children with achondroplasia between the ages of 3 years and less than 18 years who have the potential to grow.

Trong giai đoạn 3 của vòng loại World Cup 2026 khu vực châu Á, hiện có 18 đội được chia thành 3 bảng. Mỗi bảng gồm 6 đội, mỗi đội sẽ chơi 10 trận. Trong đó, 2 đội sẽ trực tiếp được vé dự VCK, còn 2 đội sẽ bị loại. Iran, Uzbekistan (bảng A), Hàn Quốc (bảng B) và Nhật (bảng C) là các đội có thành tích vượt trội hiện nay, mỗi đội đều đạt 10 điểm sau 4 trận liên tiếp, tạo ra khoảng cách rõ rệt so với các đội đứng sau. Có 80% khả năng vé dự VCK World Cup đã nằm trong tay của họ. Nếu tiếp tục chiến thắng trong các trận sắp tới, thì các đội này có thể yên tâm hoàn toàn.

Thế giới bóng đá đang đợi những quyết định quan trọng

Nhưng ở phía đối diện, mỗi bảng chỉ có 2 đội thực sự có thể ngừng lại, còn 2 đội giữa bảng sẽ tiếp tục thi đấu ở giai đoạn 4 để tranh chấp 2 suất còn lại dự World Cup hoặc suất play-off (châu Á có đến 8 vé “rưỡi” dự VCK World Cup 2026). Vì vậy, ngay cả khi không còn hy vọng vươn lên tốp 2 trong bảng, các đội cũng sẽ đấu đuổi đến cùng trong từng trận đấu, vì có nhiều cơ hội đang đợi họ. Sau 4/10 trận đã chơi, chúng ta chỉ có thể thấy đội nào đang đầy hy vọng sớm lấy vé đi World Cup, nhưng chưa thể biết rõ đội nào sẽ bị loại.

Đội tuyển Indonesia sắp đối mặt với hai đối thủ mạnh

Ở bảng C, Úc hiện đứng thứ 2 (có vé vào thẳng VCK World Cup), còn 2 đội ở vị trí cuối bảng (bị loại) là Indonesia và Trung Quốc. Nhưng khoảng cách giữa Indonesia và Trung Quốc với Úc chỉ là 2 điểm, có thể thay đổi sau một trận bất kỳ. Và cuộc đua này còn còn 6 vòng nữa. Đây chỉ là một ví dụ nhỏ để chứng tỏ rằng chưa có đội nào hoàn toàn mất hy vọng.Indonesia là đại diện duy nhất của bóng đá Đông Nam Á còn tham gia cuộc đua giành vé dự World Cup 2026. Trên thực tế, Indonesia cũng là đội bóng Đông Nam Á xuất sắc nhất trong vòng loại World Cup gần đây. Trận hòa 0-0 với Úc là trận duy nhất Indonesia chơi tại nhà, còn lại là 3 trận khách, và Indonesia hòa 2 trận, trong tình trạng dẫn bàn. Không có đội Đông Nam Á nào từng chơi như vậy với mọi đối thủ, trong suốt 4 trận ở giai đoạn mà FIFA bắt đầu phát vé cho VCK World Cup.

Uzbekistan và Indonesia hy vọng vươn lên

Vấn đề không phải là “chưa bị loại”. Indonesia vẫn còn rất nhiều hy vọng, ít nhất với mục tiêu lọt vào giai đoạn 4 của vòng loại. Một điều thú vị là Indonesia thực sự đã là đội bóng Đông Nam Á duy nhất từng dự World Cup. Đó là kỳ World Cup 1938, khi họ còn là thuộc địa của Hà Lan, với tên gọi Dutch East Indies.Trong các trận đêm nay (14.11), Uzbekistan chỉ cần không thua trên sân Qatar, sẽ tiến một bước rất lớn để củng cố hy vọng lần đầu tiên xuất hiện ở đấu trường World Cup. Qatar sẽ phải đấu với UAE 5 ngày sau, khi Uzbekistan chỉ cần gặp đội chót bảng CHDCND Triều Tiên. UAE cũng là đối thủ rất quan trọng của Uzbekistan và có thể các đội này sẽ chia điểm.Cùng với Uzbekistan, Jordan là “cánh chim lạ” đang bay bổng ở vòng loại này (đang đứng thứ 2 bảng B, sau Hàn Quốc). Iraq – Jordan sẽ là trận quyết định quan trọng trong loạt trận này. Họ đang cùng điểm, đứng dưới Hàn Quốc và cách các đội khác xa. Ai thắng trong cặp Iraq – Jordan sẽ có nhiều khả năng theo chân Hàn Quốc vào VCK World Cup.Indonesia đang chuẩn bị tinh tế cho 2 trận khó khăn liên tiếp, cả hai đều diễn ra trên sân nhà, gặp Nhật (19 giờ ngày 15.11) và Ả Rập Xê Út (ngày 19.11). Đây có thể là 2 trận quyết định đời của bóng đá Indonesia. Ả Rập Xê Út đã thay đổi huấn luyện viên trước loạt trận này.